Writhe relates to how many times the axis formed by the double helix crosses over itself, forming a supercoil.
Writhe is a highly compacting manifestation of linking number deviations since it represents the winding of the double helix upon itself.
The first prerequisite is the presence of a sequence that can fold back on itself to form a paired double helix.
First, the zinc fingers exert non-specific interaction with the backbone of a double helix whereas the second mode allows zinc fingers to specifically recognize the individual bases that bulge out.
The information contained in a double helix is no different in kind from that exhibited in the linear sequence of bases.
Interacting ions modulate this interaction : stabilization and destabilization of the double helix is more complex than simple charge neutralization.
What is certain is that published research and other evidence at all levels should feed into this process, in order to maintain the double helix of innovation and generalizability.
Many forms of the open state are possible for a single base pair, although a preference for opening towards the major groove of the double helix has been found.
