The similarity of the two correlation functions indicates that dynamical effects do not contribute substantially to catalysis.
How important are quantum mechanical nuclear motions in enzyme catalysis?
Energetically, catalysis is entirely entropic, indicating an important role of solvent reorganization, substrate positioning, and/or orientation of the reacting groups within the active site.
Energetically, catalysis is entirely entropic, indicating an important role of substrate positioning, orientation of the reacting groups within the active site, and solvent reorganization.
These findings suggest that general acid-base catalysis by ribosomal residues does not play a significant role in peptidyl transfer on the ribosome.
As expected, catalysis from the leading edge leads to a significant decrease in the atomic oxygen mass fraction near the surface.
The calculated effects on catalysis, though possibly significant for fine-tuning the kinetics, are relatively small considering the overall catalytic power of these highly efficient enzymes.
What are the roles of substrate-assisted catalysis and proximity effects in peptide bond formation by the ribosome?
