These mechanical signals can be blocked by progesterone either by a direct action of this hormone or possibly through the support of stretch-induced uterine hypertrophy.
We also verified that in our experimental conditions the three drugs inhibited progesterone-induced oocyte maturation.
In the latter, maturation was induced by progesterone (1 mg/ml).
The role of calcium in progesterone-induced meiotic maturation in amphibian oocytes remains unclear.
In amphibians, oocyte maturation is induced by progesterone produced by the follicular cells.
Neither the receptor for progesterone nor the subsequent events that lead to maturation are understood.
This finding suggests that the participation of membrane phospholipids could be the same in progesterone-induced and muscimolinduced maturation.
Not mutually exclusive is the possibility that metabolism of progesterone is enhanced, particularly by conversion of progesterone to its primary metabolite 20a-hydroxyprogesterone.
