The presence of the cofactor is sometimes essential for the polypeptide to fold.
Thus, a polypeptide folding in this encapsulated environment simply has no other species with which to form a multimolecular aggregate.
Reactions are, therefore, non-adiabatic and the essential electronic interaction between redox cofactors must be mediated by the polypeptide matrix.
These possibilities are not mutually exclusive, of course, and both could be operative for any given substrate polypeptide.
The diverse mechanisms by which cosolvents affect polypeptide conformation are beginning to be understood.
Prospects for resolving the conformations and fate of polypeptide in the chaperonin reaction 251 11.
Biological polymers such as a polypeptide chain are heteropolymers where each segment is different.
The large oligosaccharide is transferred en bloc to the nascent polypeptide chain, which is transported across or inserted into the rough endoplasmic reticulum membrane.
