methadone的示例

• Intravenous highdose methadone administered by patient controlled analgesia and continuous infusion for the treatment of cancer pain refractory to high-dose morphine.

• The opposition to methadone nevertheless continued unabated, but despite this the programme was gradually expanded.

• It can easily be contaminated, and the intravenous bag of methadone is relatively unstable and needs to be changed frequently.

• For reasons of comparability, only patients engaged in a methadone maintenance programme were included.

• Factors associated with illegal drug use among older methadone clients.

• This study focused on the use of methadone in terminal delirium.

• Finally, documentation is an important component of successful parenteral methadone treatment for pain.

• This is an open-label feasibility study of a model to evaluate sublingual methadone for cancer-related breakthrough pain.

• A small cohort of patients on methadone maintenance treatment will mature into old age.

• However, when switching to oral methadone, it is safer to assume that bioavailability will be high and oral dose is equivalent to parenteral.

• Very recently, it has also been recognized that glia become activated in response to common opioid analgesic (pain suppressive) drugs, such as morphine methadone.

• Decreased alertness on methadone was devoid of agitated features.

• The key message from the clinician should be that the benefits of methadone can far outweigh its risks.

• Profile of adolescent patients prescribed methadone in an innovative community drug service.

• Similarly, there is an established evidence base for methadone maintenance treatment and, more recently, for buprenorphine.