0 the mixture of good and bad things that happen to people -- iniş çıkışlar; çalkantılar; iyi kötü gelişmeler
Notch and cancer : best to avoid the ups and downs.
Over the years this substance has had its psychological ups and downs.
For the wounded actor, these ups and downs have the quality of a diabolical roller-coaster: highs of inflated grandiosity followed by lows of deep depression.
In like manner, the corresponding feminine psychological ups and downs and female mood-changes are seen to be linked to the moon's gradual and subtle changes.
Also, the essays themselves have ups and downs.
The activities of such spokesmen kept the expedition alive for their audience and for the scientific community despite their ups and downs.
There were commonly many transitory ups and downs during the main support phase before the transition to the escalation or institutional phases.
It is just part of family life which has its ups and downs.
