checkpoint örnekleri

• Thus, there may be an evolutionarily conserved asymmetry in the metaphase checkpoint, which may reveal something about its mechanism.

• Checkpoint proteins are crucial for cellular responses to injury, including radiation damage.

• Obviously, a processor can always transmute into a checkpoint by just standing still.

• We conclude, therefore, that the replication-sensitive checkpoints that operate during mitosis are absent or inactive during meiosis.

• An extension of this examined the possibility of checkpoints during meiosis itself, specifically during metaphase.

• We cannot exclude the possibility that the spindle assembly checkpoint acts during the first mitosis.

• Meiotic spindle and spindle checkpoint proteins are responsible for normal chromosome alignment and separation during meiosis.

• In this study, we addressed the developmental activation of the metaphase checkpoint in the zebrafish embryo.

• If the understanding of checkpoint regulation during early embryonic mitotic cell cycles is limited, similar information is totally lacking concerning meiosis.

• This checkpoint therefore provides time for mechanisms of restitution to function and prevent mitotic catastrophe.

• It is not known, however, whether the same checkpoint exists in porcine zygotes.

• These results imply the existence of checkpoint regulators which recognise early metaphase molecules and as a result delay meiotic progression.

• The metaphase checkpoint will produce a reversible metaphase arrest in many different cell types.

• However, news reports indicate that police forces were more interested in mounting illegal checkpoints and extorting bribes from civilians than in maintaining law and order.

• The second checkpoint is 'positive selection', which occurs after selection has signalled the cell to rearrange the chain genes.