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• These changes are subtle and intermittent at first and become more permanent and obvious as the disease progresses.

• A more rigorous analysis of the epidemiological impact of vaccination for meningococcal disease is essential for proper health economic estimates.

• Thus, even if we were measuring the correct symptoms, we could expect that our purely categorical disease would be hidden within a continuous symptom distribution.

• Secondary hypotheses were that abnormal psychological/ endocrine/immune measures were associated with a poorer predicted disease outcome (as evidenced by tumour pathology).

• Older knowledge, perhaps because it has been relocated to regions that are damaged by the disease process, does not fare as well.

• In the past, authors stressed the greater variability of the disease's prognosis, clinical findings and cell morphology.

• First, several simplifying assumptions surrounding the disease process and treatment were necessary to construct the model.

• Instead, they focused on the dominant urban health discourse surrounding reducing the cases of contagious diseases and improving hygiene.