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Viral vectors for gene therapy : the art of turning infectious agents into vehicles of therapeutics.
In summary, non-invasive imaging technology will help to design and improve gene therapy applications.
It is essential for the success of gene therapy vectors that an appropriate promoter is linked to the gene of interest.
Transcriptional targeting modalities in breast cancer gene therapy using adenovirus vectors controlled by alpha-lactalbumin promoter.
Deciphering the molecular mechanisms of integration site selection might have practical applications in improving the safety of retroviral vectors for use in human gene therapy.
Table 3 summarises several published studies that have utilised plasmid- and viral-mediated gene therapy to treat peripheral neuropathies.
The above definition of gene therapy formed the basis for including or excluding protocols.
This case prompted a thorough revision of the safety standards for gene therapy trials.
This fact raises the question of the feasibility of very expensive, complicated and work-intensive gene therapy approaches for these diseases.
In the future, individually designed gene therapy will probably represent a therapeutic option.
Artificial chromosomes with several therapeutic genes inserted could be important additives to conventional gene therapy if efficiently delivered to target cells.
Adenoviruses have been particularly exploited for cancer gene therapy.
All patients died at 1-29 months from gene therapy.
In addition, gene therapy offers the possibility of long-term expression of therapeutic proteins in specific cells.
Table 2 shows references that report outcome of gene therapy trials targeting cardiovascular diseases.
