Prodromal symptoms include tingling (paresthesia), itching, and pain where lumbosacral nerves innervate the skin.
Gain of function (positive) symptoms include tingling, pain, itching, crawling, and pins and needles.
Many amputees report of feeling heat, tingling, itchiness, and pain.
Overdose can lead to headache, tinnitus, numbness and tingling around the mouth and tongue, convulsions, inability to breathe, and decreased heart function.
Skin contact can lead to tingling or reddening of the skin local to the application.
When the disease occurs in the bones of the spine, neurological symptoms such as numbness and tingling may occur due to spinal nerve compression.
When the nerve is compressed, it can result in disabling symptoms like numbness, tingling, or pain in the middle three fingers.
In more advanced stages, the disease may cause tingling, increased sensitivity and pain.
