Corticomotoneuronal projections: synaptic events related to skilled movement.
The vertical axis represents normalized synaptic action density at centimeter scales.
Clearance of glutamate in the synaptic cleft depends on passive diffusion and active uptake by glutamate transporters.
Downregulation might result in a decrease in glutamate uptake and a subsequent increase in excitatory synaptic transmission.
Spontaneous synaptic activity was persistent during carbenoxolone application, indicating that chemical transmission onto these neurons was intact and only electrical transmission was disrupted.
An important example might be a neural network in which both synaptic and propagation delays contribute to its dynamic behavior.
It is possible, therefore, that reduced synaptic pruning (and therefore, elevated glucose metabolism) will be a symptom shared by several different groups with developmental disorders.
However, little is known about which calcium channels are coupled to synaptic exocytosis of glycine, which is primarily released by amacrine cells.
