They keep growing by condensation, collisional accretion and coagulation.
The disease is polymorphic, with involvement of the placenta, maternal vasculature, central nervous system, coagulation cascade, liver and kidney.
The coagulation system, including procoagulants and inhibitors, functions normally at birth.
During surgery or wounding, coagulation is normally initiated via the extrinsic coagulation pathway by the generation of tissue factor from injured cells.
These findings, besides indicating macrophage activation in experimental trypanosomiasis, may also help to explain the development of the coagulation abnormalities which accompany these infections.
Levels of coagulation factors are normally incomplete at birth and continue to mature during the first year of life.
This is a serious deficiency since, basically, the coagulation cascade is a series of enzymatic reactions that are amplified and accelerated at each step.
One of the most damaging actions triggered by the production of pro-inflammatory cytokines is the initiation of coagulation.
