0 to take things out of a bag, box, etc. -- disfare (valigia, scatolone)
Bella unpacked her suitcase. Bella ha disfatto la valigia.
1 to take out (things that are packed) -- spacchettare
He unpacked his clothes.
2 to take (clothes etc) out of (a case etc) -- disfare
Have you unpacked (your case)?