0 If something is familiar, you know it well or have seen it before -- familiare, noto
1 to know about something or have done or seen it many times before -- conoscere qualcosa
Are you familiar with his poetry? Conosci le sue poesie?
2 well-known -- familiare
3 (with with) knowing about -- familiare con
Are you familiar with the plays of Shakespeare?
4 too friendly -- familiare