0 a medical condition of the blood in which haemoglobin (= the substance in red blood cells that combines with and carries oxygen around the body, and gives blood its red colour) is not produced in the normal way
There was high-level transduction with a complete correction of the in vitro model of human thalassaemia erythropoiesis and in vivo in immune-deficient mice.
If the thalassaemia trait is present, younger family members may require genetic counselling.
Figure 1 represents the main mechanisms causing iron overload in thalassaemia.
Below, we explore investigations into treatments that are being aimed at the underlying pathophysiology of thalassaemia, including new advances in chelation.
In severe forms of thalassaemia, patients are dependent on transfusions for survival.
Despite the plethora of muations in thalassaemia, some general points can be made.
A blood film from a patient with the thalassaemia trait is largely indistinguishable from that of a patient with iron deficiency.
As a general rule, patients with thalassaemia syndromes are at increased risk of iron overload.
