Taking the 'idio ' out of 'idiosyncratic ' : predicting torsades de pointes.
It has now been withdrawn because of its adverse effects, including fatal cardiac arrhythmias, particularly 'torsades de pointes'.
A more than 10% increase should prompt concern about torsades de pointes.
Torsades de pointes have been reported in adults due to over dosage or therapeutic interaction.
From 1810 he contributed to the development of the pointes technique.
It is associated with hypokalaemia, hypocalcaemia and hypothermia and may lead to torsades de pointes.
The incidence of torsades de pointes is dose-related, and is 0.3-10.5%.
The risk appears to be dose-dependent, with an increased incidence of torsades de pointes associated with higher doses of dofetilide administered.
