Examples of mutagenic

• Virtually all known aspects of genome instability following mutagenic insult resulting in transmitted germ line mutations in mammals are based upon specific locus mutation experiments.

• Additionally, estrogen-induced tumor induction may involve receptor-mediated cell proliferation with tumor initiation by genotoxic and mutagenic events.

• Several steps are potentially mutagenic, such as exposure to high cytosolic concentrations of ethylene glycol, and the extreme dehydration that is a requisite for vitrification.

• This is the first quantitative estimate of the mutagenic effect of cryopreservation on the germ line of a metazoan.

• Moreover, where hybrid dysgenesis and mutagenic agents result in similar yet quantitatively variable genetic aberrations, accurate correlations are difficult to determine.

• Reports of hazardous chemical exposures to both male and female workers and related carcinogenic, mutagenic and now teratogenic effects are ever-increasing.

• Such protection will necessarily have reduced the exposure of bacteria to the potentially mutagenic ultraviolet and other radiation.

• This agent is a well-known carcinogen with conflicting indications of its mutagenic activity.