Warfarin embryopathy includes nasal hypoplasia and/or stippled epiphyses.
As the castrato's body grew, his lack of testosterone meant that his epiphyses (bone-joints) did not harden in the normal manner.
The male growth spurt also begins later, accelerates more slowly, and lasts longer before the epiphyses fuse.
These various epiphyses are joined to the bone by the 25th year.
This disorder affects the epiphyses, the parts of the bone where growth occurs.
The remaining cartilaginous portions of the epiphyses become thinner.
With subadults, the development of teeth, length of long bones, and union of epiphyses are used to estimate age.
The ends of epiphyses are covered with hyaline cartilage (articular cartilage).
