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The findings are more consistent with a pathway than with a fixed binding site.
The activity of cyclic nucleotide analogs is informative regarding the nature of the binding site and the structural requirements for ligand activity.
We discussed both the classical approach, assuming distributed binding sites in a smeared layer and a one-binding-site model.
Most lipocalins are beta-barrel structures with only one binding site for hydrophobic molecules.
Once assembled, the terminal regions are folded to become the binding site for the next subunits.
The nucleotide binding site is located in a pocket between the two domains.
This analysis should quantitatively reflect the free energy surface sampled by the ligand as it is pulled through the binding site.
More experiments investigating the nucleoside specificity of this binding site is under progression in our laboratory.
Managing Your Emotions
What makes me angry?
Какво ме ядосва?
Mostly，l hate when someone tries to make someone else feel bad.
Най-вече мразя, когато някой се опитва да накара някой друг да се чувства зле.
I have to admit that once, when l was actually called names.
Трябва да призная, че веднъж, когато наистина ме нарекоха.
l regretted doing this afterwards, but not full heartedly because l think l was provoked in that situation.
След това съжалявах, че го направих, но не искрено, защото смятам, че бях провокиран тази ситуация.
The most postive way of dealing with anger is talking about the problem.
Най-положителният начин за справяне с гнева е да говорите за проблема.
l talk to someone who listens, or l'll write my thoughts down on paper.
Говоря с някой, който ме слуша, или ще напиша мислите си на хартия.
Learning how to deal with anger as you're growing up is so important.
Да се научите как да се справяте с гнева, докато растете, е толкова важно.
When you're younger, you might yell,or cry when you're angry, but as you get older, you're expected to handle your emotions much better.
Когато си по-млад, може да крещиш или да плачеш, когато си ядосан, но когато остарееш, ти си се очаква да се справят с емоциите ви много по-добре.
Learning to control your emotion now will prevent you from doing something that you'll regret later on in life!
Ако се научите да контролирате емоциите си сега, ще ви попречи да направите нещо, което ще направите съжалявам по-късно в живота!
