The computation of the exact likelihood for a large pedigree with multiple loops is unaffordable in terms of computing power.
The pressure of limited time and budget makes any research unaffordable and risky.
In many developing world settings, such medicines may be unavailable or unaffordable for the majority of those who need them.
For yet others, the political democracy was unaffordable if not unviable.
Inexpensive services of little effect have poor cost-effectiveness ratios; highly cost-effective services may nevertheless be unaffordable.
For one thing, the higher price may be unaffordable to those on low incomes (such as students).
A paradigm centred on piped individual connections evolved, which persisted even after the government declared it unaffordable from the 1970s.
Very often this is an unaffordable problem, and only random subsets of data can be analysed.
