Mammary epithelial cells are continuously exposed to extracellular stimuli from surrounding epithelial cells, the stromal microenvironment and the systemic circulation.
Induction of insulin-like growth factor binding protein-1 expression in baboon endometrial stromal cells by cells of throphoblast origin.
Whether other stromal cells, such as inflammatory cells, also experience such genetic alterations remains to be investigated.
It is characterized by a combination of atrophy and proliferation in both glandular and stromal t issue.
These data support the notion of a metastatic niche formed by bone marrow and bone stromal cells that promotes metastatic cancer cell growth.
Such findings indicate that the alloimmunogenicity of the normal cornea largely resides within its epithelial and stromal layers.
However, the inappropriate temporal and spatial production of constitutive chemokines by stromal cells is an intriguing feature of chronic persistent inflammatory microenvironments.
They also have an intact immune system and the tumour cell challenge and stromal cells are of the same species.
