Due to the post-spermatogonial germ cell specificity of ifosfamide, the genetic risk is limited to a few weeks after exposure.
Stage-specific tissue and cell interactions play key roles in mouse germ cell specification.
Restoration of fertility by germ cell transplantation requires effective recipient preparation.
Apoptosis-associated signalling pathways are required for chemotherapy-mediated female germ cell destruction.
More rounded outline as compared with the primordial germ cell.
The methylation sites that survive are part of the imprinting process, passing maternal and paternal information to the final germ cell populations.
From animal studies, pro-apoptotic caspases (-2 and -3) have been implicated in the pathways of germ cell apoptosis.
At what stage is germ cell apoptosis maximum?
