The clinical application of these observations is uncertain however and the clinical ef®cacy of selective monitoring of vascular bed resistance is unproven.
With respect to both, one might reply: perhaps true, but as yet unproven.
Clearly, unpicking the causal links requires a more searching and focused enquiry if it is to move beyond generating new but unproven hypotheses.
Therefore, although pharmacological agents may be indicated on clinical grounds for co-morbid psychiatric illness, their efficacy is largely unproven.
Adipokines probably have a role in altering insulin action in disease states such as sepsis, but their role outside such states remains unproven in humans.
The curious question emerged that why, if these therapies were unproven in their clinical effectiveness, were they so powerfully dangerous to cancer patients?
However, the author does seem to perpetuate another unproven assumption, viz. that a selection procedure must be based on a dichotomous distribution.
The stability and reproducibility of these results remains unproven.
