These chemokines might be secreted by other infiltrating cells and also by stromal and epithelial cells within the tissue.
Simultaneously, a range of stromal-tissue-derived tissue repair mediators bathe the inflammatory microenvironment.
Why does inflammation persist: a dominant role for the stromal microenvironment?
Furthermore, they suggest that cytokines and chemokines made by infiltrating leukocytes and resident stromal cells contribute to this switch.
Another issue not to be ignored is the stromal contribution to urokinase production.
However, recent studies report that these changes also occur in stromal fibroblasts.
We proceed under the stated assumptions because we believe that they reflect, phenomenologically, the relative importance of the effects of degradation, necrosis and stromal consumption.
They also have an intact immune system and the tumour cell challenge and stromal cells are of the same species.
