0 a condition in which scar tissue grows in the bone marrow so that not enough blood cells are produced for the body
The symptoms associated with myelofibrosis are variable and in more than 50% of patients include marked lassitude, loss of weight and night sweats.
This distinction is important since the treatment of polycythemia vera carries a serious risk of myelofibrosis and acute leukemia.
A leucoerythroblastic blood film, where nucleated red blood cells and early white cell forms appear, is strongly suggestive of myelofibrosis or marrow replacement by malignancy (both haematological and non-haematological).
The cause and risk factors for primary myelofibrosis are unknown.
Myelofibrosis is a myeloid malignancy associated with anemia, splenomegaly, and constitutional symptoms.
It is common in people who have chronic idiopathic myelofibrosis.
It is part of the presentation in acute panmyelosis with myelofibrosis.
Older terms include myelofibrosis with myeloid metaplasia and agnogenic myeloid metaplasia.
