However, the full results of a major double-blinded study are to be published, and this publication should provide valuable additional evidence (27).
This is a randomized prospective, double-blinded study with a group receiving placebo compared with three schedules of dosage with triiodothyronine (0.4, 0.6, and 0.8 micrograms per kilogram).
In a large double-blinded randomized controlled trial, reduction in hot flashes was not statistically significant but showed a strong trend towards improvement.
Trials are typically randomized and double-blinded, with two (statistically) identical groups of patients being compared.
More recently, a double-blinded, placebo-controlled trial focusing on women found that creatine, when used along with an antidepressant, exerted a powerful and rapid antidepressant effect.
In randomized, double-blinded trials, individuals on different dopamine agonists, including dihydroergocryptine, did not differ in discontinuation rate associated with adverse events.
Clinical trials are often double-blinded so that the researchers also do not know which test subjects are receiving the active or placebo treatment.
Anonymity may be unilateral or reciprocal (single- or double-blinded reviewing).