This will need to be established using animal models that produce low baseline glucocorticoid concentrations without removing glucocorticoids entirely from systemic circulation (as is the case in adrenalectomy).
During this process one or two adrenal glands can be removed and this is known as adrenalectomy.
Following adrenalectomy, epinephrine disappears below the detection limit in the blood stream.
Bilateral adrenalectomy is another treatment which provides immediate reduction of cortisol level and control of hypercortisolism.
All of these conditions, with the exception of adrenalectomy, cause a large elevation of circulating aldosterone.
